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Understanding Genetic Variation (SNPs)


National Cancer Institute

Title Page

1. Cancer - Different Fates

2. Cancer - A Complex Disease

3. SNPS May Be the Solution

4. What Is the Human Genome?

5. DNA and Chromosome Structure

6. The Genome Contains Genes

7. Variation in the Human Genome

8. What Is Variation in the Genome?

9. Variations Causing No Changes

10. Variations Causing Harmless Changes

11. Variations Causing Harmful Changes

12. Variations Causing Latent Changes

13. SNPS Are the Most Common Type of Variation

14. Why Are SNPs Significant?

15. Amino Acids

16. Amino Acid Side Chains Water-Loving

17. Amino Acid Side Chains Oil-Loving

18. Amino Acid Side Chains Ambivalent

19. Proteins

20. Genes to Proteins I

21. Genes to Proteins II

22. Genes to Proteins III

23. Protein Folding and Function

24. SNPs in Coding Regions No Changes in Protein

25. SNPs in Coding Regions - Subtle, Harmless Changes in Protein

26. SNPs in Coding Regions - Harmful Changes in Protein – Mutations

27. SNPs in Coding Regions - Subtle Changes in Proteins That Only Switch on Under Certain Conditions

28. Smoking and Susceptibility to Lung Cancer

29. Smoking and Susceptibility to Lung Cancer - SNPs in Carcinogen-Making Proteins

30. Smoking and Susceptibility to Lung Cancer - SNPs in Detoxifying Proteins

31. Arylamines and Bladder Cancer

32. SNPs and Bladder Cancer Risk

33. Not the Whole Story

34. SNPs and Drug Interactions

35. SNPs in Noncoding Regions - Markers for Genes

36. SNP Maps

37. Individual SNP Profiles

38. SNPs Profiles and Response to Drug Therapy

39. SNP Profiles May Help to Identify Cancer Genes

40. SNPs and Cancer Risk

41. Summary - SNPs and Cancer Research