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39. Mutations in Cancer Susceptibility Genes: BRCA2

Mutations in Cancer Susceptibility Genes: <i>BRCA2</i>

 

Here is an example of the mutations seen in the BRCA2 breast cancer susceptibility gene.

Inheriting these mutated alleles greatly increases a person's lifetime risk for developing cancer. This may explain why cancers linked to germline mutations in susceptibility genes often occur at an earlier age and in multiple sites.